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Target intelligence / Profile preview
ZSCAN16 antisense RNA 1 (ZSCAN16-AS1)
- Target
- ZSCAN16-AS1
- Molecular classification
- Long non-coding RNA, Other
01
Overview
ZSCAN16 antisense RNA 1 (ZSCAN16-AS1) is a long non-coding RNA (lncRNA) located on human chromosome 6, transcribed antisense to the ZSCAN16 gene[2][5]. ZSCAN16-AS1 is predominantly cytoplasmic and promotes oncogenic properties in hepatocellular carcinoma (HCC) by acting as a competing endogenous RNA (ceRNA) that sequesters miR-451a, thereby increasing the expression of activating transcription factor 2 (ATF2)[1][5]. Elevated ZSCAN16-AS1 expression is associated with increased tumor cell proliferation, migration, and invasion, as well as reduced apoptosis in HCC[1]. High levels of ZSCAN16-AS1 correlate with poor prognosis in HCC patients, suggesting its utility as a biomarker[1][5]. As a lncRNA, ZSCAN16-AS1 is not a receptor, enzyme, or canonical therapeutic target, but may represent a potential molecular target for RNA-based therapies in cancer[1][3][5].
- Other names
- ZSCAN16-AS1ZSCAN16 AS1
02
Biological functions
Competing endogenous RNA activityRegulation of gene expressionOncogenic lncRNA in hepatocellular carcinomaModulation of microRNA (miR-451a) activity
03
Disease associations
Cancer (hepatocellular carcinoma)Other
04
Biomarkers
Potential prognostic biomarker for hepatocellular carcinoma (high expression associated with poor prognosis)
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