Zyg-11 family member B, cell cycle regulator (ZYG11B)

Zyg-11 family member B, cell cycle regulator (ZYG11B) is a substrate recognition component of a CUL2-based E3 ubiquitin ligase complex, functioning primarily in the selective degradation of proteins bearing specific N-terminal degrons, which is critical for protein quality control, cell cycle progression, and the regulation of apoptosis. ZYG11B and its homologues interact with Elongin C and CUL2 via a conserved VHL-box motif, thereby forming a functional E3 ligase complex that modulates proteasomal degradation pathways. The biological activities of ZYG11B include facilitating timely cell cycle transitions, aiding in the removal of defective or misfolded proteins, clearing proteolytic fragments generated during apoptosis, and contributing to antiviral responses by enhancing the cGAS pathway. Human diseases associated with mutations in ZYG11B include craniofacial microsomia and familial hypertrophic cardiomyopathy; however, no drugs are currently known to target this molecule directly. It is considered an intracellular regulatory/protein quality control factor rather than a classical receptor or enzyme.

Other names

ZYG11BZYG11ZYGC9orf60ZYG11BLzyg-11 family member B, cell cycle regulator

As a substrate adapter in CUL2-based E3 ubiquitin ligase complexes, it promotes targeted degradation of proteins with specific N-terminal motifs (e.g., N-terminal glycine) by the proteasome ([targeting N-degron pathway])