Zymogen granule protein 16 homolog B (ZG16B)

Zymogen granule protein 16 homolog B (ZG16B), also called pancreatic adenocarcinoma up-regulated factor (PAUF), is a secretory lectin-like oncoprotein characterized by a Jacalin-related β-prism fold. It is primarily identified as a growth and metastatic factor in pancreatic ductal adenocarcinoma, and aberrantly expressed in other tumors, such as breast, gastric, and ovarian cancers. ZG16B executes multiple biological roles, including carbohydrate binding, regulation of cell adhesion, apoptosis, angiogenesis, and modulation of immune responses via TLR2/TLR4 and related signaling pathways. It is actively involved in tumor proliferation, migration, and immune evasion, and is currently being explored as a diagnostic/prognostic biomarker and therapeutic target. Therapies under investigation include monoclonal antibodies and FAK inhibitors, with ongoing trials specifically in pancreatic cancer. ZG16B has considerable promise but also complexity, playing both immunostimulatory and immunosuppressive roles in the tumor microenvironment

Other names

Pancreatic adenocarcinoma up-regulated factor (PAUF)UNQ773/PRO1567HRPE773JCLN2Jacalin-like lectin domain containing 2Endocrine and exocrine proteinEECPZymogen granule protein 16B

Monoclonal antibodies like Ulenistamab block ZG16B-mediated adhesion and angiogenesis FAK inhibitors disrupt ZG16B-dependent cell adhesion and metastasis Chemotherapy agents (gemcitabine/5-FU) shown to interact with ZG16B-expressing tumors, potentially enhancing effect or resistance Modulation of TLR2/TLR4-related signaling pathways for immune response and tumor cell survival