Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
ZZ-type zinc finger-containing protein 3 (ZZZ3)
- Target
- ZZZ3
- Molecular classification
- Chromatin-associated protein, Histone modification complex (component of a histone acetyltransferase complex), Epigenetic reader (specifically, N-terminal histone H3 reader), Other (zinc finger protein)
01
Overview
ZZ-type zinc finger-containing protein 3 (ZZZ3) is a highly conserved subunit of the Ada-two-A-containing (ATAC) histone acetyltransferase complex in mammals[1][2]. It acts as a chromatin-associated epigenetic reader by specifically recognizing the N-terminal region of histone H3, with a preference for the acetylated lysine 4 (H3K4ac) mark. This interaction is critical for the efficient recruitment and chromatin association of the ATAC complex, facilitating histone acetylation at gene promoters and promoting global gene activation. ZZZ3 contains both a SANT domain (associated with DNA binding) and a distinctive ZZ-type zinc finger domain, which directly mediates histone binding. Loss or mutation of ZZZ3 diminishes ATAC-dependent promoter histone H3 acetylation and leads to downregulation of genes involved in key cellular functions such as ribosome biogenesis and the cell cycle, highlighting its essential role in chromatin regulation and transcriptional control[1][2]. There is currently no evidence of direct drug targeting, biomarker use, or specific therapeutic interventions involving ZZZ3.
- Other names
- ZZZ3ATAC component 1 homologATAC1DKFZP564I052zinc finger, ZZ domain containing 3ATAC component 1 homolog (Drosophila)ZZ-type zinc finger-containing protein 3
02
Biological functions
Maintenance of histone acetylationGene activation and regulation of transcriptionPromoter targeting of the ATAC complexEpigenetic regulation (binds acetylated histone H3, favors open chromatin)
03
Disease associations
Other (dysregulation may affect cell growth, ribosome biogenesis, DNA replication, and cell cycle pathways; direct links to disease such as cancer not strongly established)
Beyond the preview
Go deeper on ZZ-type zinc finger-containing protein 3 (ZZZ3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ZZ-type zinc finger-containing protein 3 (ZZZ3).