Sciatic perineural levobupivacaine ± clonidine infusion to prevent phantom limb pain and cardiac morbidity after lower limb amputation

Phase 4, randomised trial in phantom limb pain (PLP), postoperative pain and arrhythmogenic cardiomyopathy (ACM) comparing Saline infusion (placebo), Levobupivacaine infusion and Levobupivacaine + clonidine infusion (3 arms). Primary endpoints: Incidence of phantom limb pain at 12 months and Cardiac outcomes after lower limb amputation. Started Apr 2007; status: terminated.