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Lapatinib combinations for recurrent brain metastases from HER2-positive breast cancer after cranial radiotherapy

2006-005912-28Phase 2Completed

Sponsor
GSK
Start
Feb 2007
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Countries
1
01

Overview

Phase 2, open-label trial of lapatinib, capecitabine and topotecan in breast cancer and brain metastases (2 arms), sponsored by GSK. Primary endpoint: CNS objective response rate. Started Feb 2007; status: completed.

02

Drugs

lapatinibcapecitabinetopotecan
03

Conditions

breast cancerbrain metastases

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