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6R-BH4 for endothelial function in CADASIL
2007-004370-55Phase 2Completed
- Sponsor
- ASST Grande Ospedale Metropolitano Niguarda
- Start
- Dec 2007
- Modality
- Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Countries
- 1
01
Overview
Phase 2, randomised trial in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) comparing Phenoptin with Placebo (2 arms). Primary endpoint: Change in endothelial function by flow-mediated dilation. Started Dec 2007; status: completed.
02
Drugs
sapropterin
03
Conditions
cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
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