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Physostigmine salicylate for early postoperative restoration of vigilance and cognition after cardiopulmonary bypass surgery
2007-007174-35Phase 4Completed
- Sponsor
- Franz Köhler Chemie
- Start
- Nov 2008
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Countries
- 1
01
Overview
Phase 4, randomised trial in post-operative cognitive decline (POCD) and Impaired vigilance comparing Physostigmine salicylate with Placebo (2 arms). Primary endpoints: Improvement of postoperative vigilance and Improvement of postoperative cognitive function. Started Nov 2008; status: completed.
02
Drugs
physostigmine
03
Conditions
post-operative cognitive decline (POCD)Impaired vigilance
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