Trial intelligence / Profile preview

Treosulfan and 4 Gy TBI conditioning with rapamycin-based graft-versus-host disease prophylaxis for allogeneic stem cell transplantation

2011-001534-42Phase 2Completed

Sponsor
Fondazione Centro San Raffaele
Start
May 2012
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Countries
1
01

Overview

Phase 2, open-label, single-arm trial of treosulfan, fludarabine, sirolimus, antithymocyte immunoglobulin, rituximab and 1 more in hematopoietic malignancies, leukemia, multiple myeloma (MM) and 1 more, sponsored by Fondazione Centro San Raffaele. Primary endpoint: Progression-free survival at 1 year. Started May 2012; status: completed.

02

Drugs

treosulfanfludarabinesirolimusantithymocyte immunoglobulinrituximab
03

Conditions

hematopoietic malignanciesleukemiamultiple myeloma (MM)lymphoma

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