Trial intelligence / Profile preview

DA-EPOCH-R induction followed by nivolumab consolidation in newly diagnosed double-hit/triple-hit high-grade B-cell lymphoma

2017-003631-12Phase 2Active

Sponsor
HOVON
Start
May 2018
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Countries
1
01

Overview

Phase 2, open-label, single-arm trial of nivolumab, rituximab, cyclophosphamide, doxorubicin, etoposide and 2 more in large-cell lymphoma and diffuse large B-cell lymphoma (DLBCL), sponsored by HOVON. Primary endpoint: 12-month disease-free survival. Started May 2018; status: active.

02

Drugs

nivolumabrituximabcyclophosphamidedoxorubicinetoposide
03

Conditions

large-cell lymphomadiffuse large B-cell lymphoma (DLBCL)

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