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PenVe feasibility trial in irradiated head and neck cancer patients
2018-001153-27Phase 2Unknown
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Start
- Oct 2018
- Modality
- Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Countries
- 1
01
Overview
Phase 2, randomised, open-label trial in osteoradionecrosis (ORN) and radiation-induced fibrosis (RIF) comparing Pentoxifylline + tocopherol with Standard of care (2 arms). Primary endpoint: Feasibility of a randomized controlled trial of pentoxifylline plus vitamin E versus standard care. Status: unknown.
02
Drugs
pentoxifyllinetocopherol
03
Conditions
osteoradionecrosis (ORN)radiation-induced fibrosis (RIF)
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