Trial intelligence / Profile preview

Phase 3 study of eplontersen in transthyretin-mediated amyloid cardiomyopathy

2019-002835-27Phase 3Active

Sponsor
Ionis Pharmaceuticals
Start
Nov 2019
Modality
Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Countries
1
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Overview

Phase 3, randomised, double-blind trial in amyloidotic transthyretin cardiomyopathy (ATTR-CM) comparing eplontersen plus standard of care with placebo plus standard of care (2 arms). Primary endpoint: Composite of cardiovascular death and recurrent cardiovascular clinical events. Started Nov 2019; status: active.

02

Drugs

eplontersen
03

Conditions

amyloidotic transthyretin cardiomyopathy (ATTR-CM)

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