Trial intelligence / Profile preview

CARMAN trial of early CAR-T intensification versus standard first-line therapy in high-risk mantle cell lymphoma

2022-502405-15-01Phase 2Authorised

Sponsor
LMU Klinikum
Start
Apr 2024
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Countries
5
01

Overview

Phase 2, randomised, open-label trial of brexucabtagene autoleucel, ibrutinib and rituximab in mantle cell lymphoma (MCL) (2 arms), sponsored by LMU Klinikum. Primary endpoint: Failure-free survival. Planned start Apr 2024; status: authorised.

02

Drugs

brexucabtagene autoleucelibrutinibrituximab
03

Conditions

mantle cell lymphoma (MCL)

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