Trial intelligence / Profile preview

Phase 1/2 Study of BLU-451 in Advanced Cancers with EGFR Exon20 Insertion Mutations

2022-502527-21-00Phase 2Authorised

Sponsor
Blueprint Medicines
Start
Oct 2023
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Countries
10
01

Overview

Phase 2, open-label trial of BLU-451 in non-small cell lung cancer (NSCLC) and Nonhematologic neoplasms (2 arms), sponsored by Blueprint Medicines. Primary endpoints: Maximum tolerated dose (MTD) determination: Dose-limiting toxicity (DLT) rate, Recommended Phase 2 dose (RP2D) determination and 2 more. Planned start Oct 2023; status: authorised.

02

Drugs

BLU-451
03

Conditions

non-small cell lung cancer (NSCLC)Nonhematologic neoplasms

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