Trial intelligence / Profile preview

Pembrolizumab and chemotherapy with or without MK-4830 as neoadjuvant treatment for high-grade serous ovarian cancer

2023-505005-16-00Phase 2Completed

Sponsor
Merck & Co.
Start
Jul 2022
Modality
Immune Checkpoint Inhibitors → Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
Countries
11
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Overview

Phase 2, randomised trial in ovarian cancer, primary peritoneal cancer (PPC) and fallopian tube cancer (PFTC) comparing Keytruda + carboplatin + paclitaxel with Keytruda + MK-4830 + carboplatin + paclitaxel (2 arms). Primary endpoint: Change from baseline in circulating tumor deoxyribonucleic acid. Started Jul 2022; status: completed.

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Drugs

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Conditions

ovarian cancerprimary peritoneal cancer (PPC)fallopian tube cancer (PFTC)

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