Trial intelligence / Profile preview

PALM: Precision therapy versus standard therapy in AML and MDS in elderly

2023-509092-16-00Phase 2Completed

Sponsor
Akershus University Hospital
Start
Oct 2024
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, randomised trial of decitabine, azacitidine, venetoclax, sorafenib, etoposide and 4 more in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and 1 more (2 arms), sponsored by Akershus University Hospital. Primary endpoint: Cost-effectiveness of precision therapy. Started Oct 2024; status: completed.

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Drugs

decitabineazacitidinevenetoclaxsorafenibetoposide
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Conditions

acute myeloid leukemia (AML)myelodysplastic syndrome (MDS)chronic myelomonocytic leukemia (CMML)acute leukemia of ambiguous lineage (ALAL)

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