Trial intelligence / Profile preview

CRIMI study in bladder-sparing chemoradiotherapy with nivolumab with or without ipilimumab for muscle-invasive bladder cancer

2023-509460-19-00Phase 2Completed

Sponsor
Amsterdam University Medical Center
Start
Oct 2024
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Countries
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Overview

Phase 2, open-label trial of nivolumab, ipilimumab, mitomycin c and capecitabine in muscle-invasive bladder cancer (MIBC) and transitional cell carcinoma of the bladder (TCC) (2 arms), sponsored by Amsterdam University Medical Center. Primary endpoints: Toxicity and dose-limiting toxicity and Disease-free survival. Started Oct 2024; status: completed.

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Drugs

nivolumabipilimumabmitomycin ccapecitabine
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Conditions

muscle-invasive bladder cancer (MIBC)transitional cell carcinoma of the bladder (TCC)

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