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DESTINY-Breast12: Trastuzumab deruxtecan in previously treated HER2-positive metastatic breast cancer with or without brain metastases
2024-510588-53-00Phase 4Authorised
- Sponsor
- AstraZeneca
- Start
- Sep 2024
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Countries
- 14
01
Overview
Phase 4, open-label trial of trastuzumab deruxtecan in breast cancer (2 cohorts), sponsored by AstraZeneca. Primary endpoints: ORR in participants without baseline brain metastasis (Cohort 1) and PFS in participants with baseline brain metastasis (Cohort 2). Planned start Sep 2024; status: authorised.
02
Drugs
trastuzumab deruxtecan
03
Conditions
breast cancer
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