Trial intelligence / Profile preview

Neoadjuvant chemotherapy + SBRT ± durvalumab ± oleclumab in luminal B breast cancer

2024-511849-19-00Phase 2Authorised

Sponsor
Institut Jules Bordet
Start
Oct 2024
Modality
Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Countries
2
01

Overview

Phase 2, randomised trial of durvalumab, oleclumab, doxorubicin, paclitaxel and cyclophosphamide in breast cancer (3 arms), sponsored by Institut Jules Bordet. Primary endpoint: Residual cancer burden (RCB 0–1 vs RCB 2–3) at surgery. Planned start Oct 2024; status: authorised.

02

Drugs

durvalumaboleclumabdoxorubicinpaclitaxelcyclophosphamide
03

Conditions

breast cancer

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