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Phase 2 trial of CDR132L in heart failure with reduced/mildly reduced ejection fraction and left ventricular hypertrophy
2024-515797-27-00Phase 2Authorised
- Sponsor
- Novo Nordisk
- Start
- Jun 2025
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Countries
- 10
01
Overview
Phase 2, randomised, double-blind trial in heart failure with reduced ejection fraction (HFrEF), heart failure with mid-range ejection fraction (HFmrEF), left ventricular hypertrophy (LVH) and 1 more comparing CDR132L with Placebo (2 arms). Primary endpoint: Change in normalized miR-132 from baseline to week 24. Planned start Jun 2025; status: authorised.
02
Drugs
CDR132L
03
Conditions
heart failure with reduced ejection fraction (HFrEF)heart failure with mid-range ejection fraction (HFmrEF)left ventricular hypertrophy (LVH)dilated cardiomyopathy (DCM)
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