Trial intelligence / Profile preview

KEYMAKER-U03 Substudy 03C in recurrent clear cell renal cell carcinoma after adjuvant anti-PD-(L)1 therapy

2024-516437-12-00Phase 2Authorised

Sponsor
Merck & Co.
Start
Aug 2025
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
Countries
8
01

Overview

Phase 2, open-label, single-arm trial of belzutifan and zanzalintinib in clear cell renal cell carcinoma (ccRCC), sponsored by Merck & Co. Primary endpoints: Dose-limiting toxicities, Adverse events and 2 more. Planned start Aug 2025; status: authorised.

02

Drugs

belzutifanzanzalintinib
03

Conditions

clear cell renal cell carcinoma (ccRCC)

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