Trial intelligence / Profile preview

Patient-guided dose reduction of tyrosine kinase inhibitors in chronic myeloid leukemia (RODEO)

2024-516511-24-00Phase 4Completed

Sponsor
Radboud University Medical Center
Start
Nov 2024
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
Countries
1
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Overview

Phase 4, open-label, single-arm trial of imatinib, ponatinib, bosutinib, nilotinib and dasatinib in chronic myelogenous leukemia (CML), sponsored by Radboud University Medical Center. Primary endpoint: Treatment failure at 12 months after first dose reduction. Started Nov 2024; status: completed.

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Drugs

imatinibponatinibbosutinibnilotinibdasatinib
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Conditions

chronic myelogenous leukemia (CML)

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