Trial intelligence / Profile preview

cfDNA-guided second-line treatment initiation in relapsed DLBCL/HGBCL

2024-518275-64-00Phase 2Authorised

Sponsor
Institute of Hematology and Transfusion Medicine
Start
Dec 2024
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Countries
1
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Overview

Phase 2, open-label trial of glofitamab, polatuzumab vedotin, lisocabtagene maraleucel, axicabtagene ciloleucel, tafasitamab and 8 more in diffuse large B-cell lymphoma (DLBCL) and large-cell lymphoma (3 arms), sponsored by Institute of Hematology and Transfusion Medicine. Primary endpoints: Overall response rate for cfDNA-guided second-line treatment and Grade 3-4 adverse reaction incidence. Planned start Dec 2024; status: authorised.

02

Drugs

glofitamabpolatuzumab vedotinlisocabtagene maraleucelaxicabtagene ciloleuceltafasitamab
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Conditions

diffuse large B-cell lymphoma (DLBCL)large-cell lymphoma

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