Trial intelligence / Profile preview

ONO-4578 plus nivolumab, mFOLFOX6, and bevacizumab versus standard of care in first-line PD-L1-positive advanced colorectal cancer

2024-519590-19-00Phase 2Authorised

Sponsor
Ono Pharmaceutical
Start
Nov 2025
Modality
Small Molecules
Countries
6
01

Overview

Phase 2, randomised, open-label trial of ONO-4578 in colorectal cancer (CRC) (3 arms), sponsored by Ono Pharmaceutical. Primary endpoints: Safety and tolerability and Overall response rate by blinded independent central review. Planned start Nov 2025; status: authorised.

02

Drugs

ONO-4578
03

Conditions

colorectal cancer (CRC)

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