Trial intelligence / Profile preview

TNT-OES-2: Total Neoadjuvant Therapy for Node-Positive Esophageal and EGJ Adenocarcinoma

2025-521158-40-00Phase 2Authorised

Sponsor
Erasmus MC
Start
Aug 2025
Modality
Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, randomised, open-label trial of folinic acid, fluorouracil, oxaliplatin, docetaxel, paclitaxel and 1 more in esophageal adenocarcinoma (EAC) and gastroesophageal junction adenocarcinoma (2 arms), sponsored by Erasmus MC. Primary endpoint: Progression-free survival. Planned start Aug 2025; status: authorised.

02

Drugs

folinic acidfluorouraciloxaliplatindocetaxelpaclitaxel
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Conditions

esophageal adenocarcinoma (EAC)gastroesophageal junction adenocarcinoma

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Study design & results

Available in the Gosset platform where reported.

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Available in the Gosset platform where reported.

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