Trial intelligence / Profile preview

Vestal: Venetoclax-augmented treosulfan-based reduced-intensity conditioning before allo-HCT in AML/MDS

2025-521372-62-00Phase 2Authorised

Sponsor
University Hospital Tübingen
Start
Sep 2025
Modality
Small Molecules
Countries
1
01

Overview

Phase 2, open-label, single-arm trial of venetoclax in acute myeloid leukemia (AML), Myelodysplastic syndrome with excess blasts and acute myeloid leukemia (MDS-EB/AML) and myelodysplastic syndrome (MDS), sponsored by University Hospital Tübingen. Primary endpoint: Overall survival at day 28 after allogeneic hematopoietic cell transplantation. Planned start Sep 2025; status: authorised.

02

Drugs

venetoclax
03

Conditions

acute myeloid leukemia (AML)Myelodysplastic syndrome with excess blasts and acute myeloid leukemia (MDS-EB/AML)myelodysplastic syndrome (MDS)

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