Trial intelligence / Profile preview

ADX-038 phase 2 study in complement-mediated kidney disease

2025-521752-26-00Phase 2Authorised

Sponsor
ADARx Pharmaceuticals
Start
Apr 2026
Modality
Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Countries
8
01

Overview

Phase 2, open-label, single-arm trial of agazisiran in complement-mediated kidney disease, IgA nephropathy (IgAN), Complement 3 glomerulopathy (C3G) and 1 more, sponsored by ADARx Pharmaceuticals. Primary endpoint: Incidence and severity of treatment-emergent adverse events. Planned start Apr 2026; status: authorised.

02

Drugs

agazisiran
03

Conditions

complement-mediated kidney diseaseIgA nephropathy (IgAN)Complement 3 glomerulopathy (C3G)Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)

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