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OPERA-02: palazestrant + ribociclib versus letrozole + ribociclib in first-line ER-positive, HER2-negative advanced breast cancer
2025-522873-12-00Phase 3Authorised
- Sponsor
- Olema Oncology
- Start
- Feb 2026
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Small Molecules
- Countries
- 27
01
Overview
Phase 3, randomised, double-blind trial in breast cancer comparing Palazestrant + ribociclib with Letrozole + ribociclib (2 arms). Primary endpoint: Local investigator-assessed progression-free survival. Planned start Feb 2026; status: authorised.
02
Drugs
palazestrantribociclibletrozole
03
Conditions
breast cancer
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