Trial intelligence / Profile preview

INFLUENCE Trial: Optimizing fludarabine exposure during lymphodepletion for CAR T cell therapy in B-ALL

2025-523096-34-00Phase 3Authorised

Sponsor
Princess Máxima Center for Pediatric Oncology
Start
Apr 2026
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Countries
5
01

Overview

Phase 3, randomised trial of fludarabine in B cell acute lymphoblastic leukemia (B-ALL) (2 arms), sponsored by Princess Máxima Center for Pediatric Oncology. Primary endpoint: Event-free survival. Planned start Apr 2026; status: authorised.

02

Drugs

fludarabine
03

Conditions

B cell acute lymphoblastic leukemia (B-ALL)

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