Trial intelligence / Profile preview

First-Time-in-Human Study of GSK5471713 in Adults With Metastatic Castration-Resistant Prostate Cancer

2025-523874-17-00Phase 2Authorised

Sponsor
GSK
Start
Oct 2026
Modality
PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Countries
8
01

Overview

Phase 2, open-label, single-arm trial of GSK5471713 in castration-resistant prostate cancer (CRPC), sponsored by GSK. Primary endpoints: Dose-limiting toxicities at each dose level, Adverse events, serious adverse events, and adverse events leading to dose modifications (incidence) and 1 more. Planned start Oct 2026; status: authorised.

02

Drugs

GSK5471713
03

Conditions

castration-resistant prostate cancer (CRPC)

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