Trial intelligence / Profile preview

STELA biomarker-guided de-escalation study in advanced clear-cell renal cell carcinoma

2026-525749-54-00Phase 2Withdrawn

Sponsor
Institute of Oncology Ljubljana
Start
Oct 2026
Modality
Immune Checkpoint Inhibitors → Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
Countries
1
01

Overview

Phase 2, randomised, open-label trial in clear cell renal cell carcinoma (ccRCC) comparing Pembrolizumab + lenvatinib strategy with Nivolumab + cabozantinib strategy (2 arms). Primary endpoint: 12-month progression-free survival. Planned start Oct 2026; status: withdrawn.

02

Drugs

pembrolizumabnivolumabcabozantiniblenvatinib
03

Conditions

clear cell renal cell carcinoma (ccRCC)

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