Trial intelligence / Profile preview

CINK-CAR: CNS administration of CART-NKG2D or NKIL15 cells in pediatric and young adult high-grade CNS tumors

2026-525876-24-00Phase 2Authorised

Sponsor
Hospital Universitario La Paz
Start
Jul 2026
Modality
CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies, CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies
Countries
1
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Overview

Phase 2, randomised, open-label trial in central nervous system tumor, medulloblastoma, Atypical teratoid rhabdoid tumor (ATRT) and 2 more comparing CART45RA-NKG2D CNS arm with NKIL15 CNS arm (2 arms). Primary endpoint: Safety and tolerability of CART45RA-NKG2D or NKIL15. Planned start Jul 2026; status: authorised.

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Drugs

CART45RA-NKG2DNKIL15
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Conditions

central nervous system tumormedulloblastomaAtypical teratoid rhabdoid tumor (ATRT)ependymomaglioma

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