Paracetamol versus indomethacin for hemodynamically significant patent ductus arteriosus in very preterm infants

Phase 4, randomised, double-blind trial in patent ductus arteriosus (PDA) comparing Oral paracetamol + intravenous placebo with Intravenous indomethacin + oral placebo (2 arms). Primary endpoint: Composite primary outcome: ductus arteriosus closure or at least 50% reduction in DA diameter from pretreatment. Planned start Nov 2015; status: not yet recruiting.