Trial intelligence / Profile preview

Alternating lorlatinib and crizotinib for refractory ALK-rearranged advanced non-small cell lung cancer

ACTRN12619000844145Phase 2Completed

Sponsor
Royal North Shore Hospital
Start
Jun 2019
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
Countries
1
01

Overview

Phase 2, open-label, single-arm trial of lorlatinib and crizotinib in non-small cell lung cancer (NSCLC) and ALK-positive non-small cell lung cancer, sponsored by Royal North Shore Hospital. Primary endpoint: Time to treatment failure with alternating ALK inhibitor therapy. Started Jun 2019; status: completed.

02

Drugs

lorlatinibcrizotinib
03

Conditions

non-small cell lung cancer (NSCLC)ALK-positive non-small cell lung cancer

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