Trial intelligence / Profile preview

COMPARE-CMD Part 1 acute drug testing in coronary microvascular dysfunction

ACTRN12625001179426Phase 4Not yet recruiting

Sponsor
Sydney Local Health District
Start
Oct 2025
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Countries
1
01

Overview

Phase 4, randomised, open-label trial of clevidipine, esmolol, epoprostenol, nitroglycerin, sildenafil and 1 more in Coronary Small Vessel Disease (CMD) and angina pectoris (2 arms), sponsored by Sydney Local Health District. Primary endpoint: Change in index of microvascular resistance. Planned start Oct 2025; status: not yet recruiting.

02

Drugs

clevidipineesmololepoprostenolnitroglycerinsildenafil
03

Conditions

Coronary Small Vessel Disease (CMD)angina pectoris

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