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Bisphosphonates for prevention and treatment of aseptic loosening after total hip arthroplasty
ChiCTR1900022821Phase 4Recruiting
- Sponsor
- Sun Yat-sen Memorial Hospital
- Start
- Jun 2019
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Countries
- 1
01
Overview
Phase 4, randomised, open-label trial of alendronate, zoledronic acid, calcium carbonate, vitamin d and calcitriol in aseptic loosening of hip arthroplasty (ALHA) (4 arms), sponsored by Sun Yat-sen Memorial Hospital. Primary endpoints: Incidence of aseptic loosening of artificial joints and Bone mineral density in Gruen zones 1-7 around the prosthesis. Started Jun 2019; status: recruiting.
02
Drugs
alendronatezoledronic acidcalcium carbonatevitamin dcalcitriol
03
Conditions
aseptic loosening of hip arthroplasty (ALHA)
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