Trial intelligence / Profile preview

Phase II study of orelabrutinib + rituximab + methotrexate in untreated primary central nervous system lymphoma

ChiCTR2100049862Phase 2Not yet recruiting

Sponsor
Department of Lymphoma and Plasmacytoma, Senior Department of Hematology, Chinese PLA General Hospital
Start
Jul 2021
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, open-label, single-arm trial of orelabrutinib, rituximab and methotrexate in primary central nervous system lymphoma (PCNSL), sponsored by Department of Lymphoma and Plasmacytoma, Senior Department of Hematology, Chinese PLA General Hospital. Primary endpoints: Overall response rate and Complete response rate. Planned start Jul 2021; status: not yet recruiting.

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Drugs

orelabrutinibrituximabmethotrexate
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Conditions

primary central nervous system lymphoma (PCNSL)

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