Trial intelligence / Profile preview

Ivonescimab plus targeted and intrathecal therapy for leptomeningeal metastasis in EGFR/ALK-positive NSCLC

ChiCTR2500109516Phase 2Not yet recruiting

Sponsor
Nanjing Drum-Tower Hospital
Start
Sep 2025
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Countries
1
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Overview

Phase 2, open-label, single-arm trial of ivonescimab in non-small cell lung cancer (NSCLC) and Carcinomatous Meningitis (CM), sponsored by Nanjing Drum-Tower Hospital. Primary endpoints: CSF tumor markers and Progression-free survival (PFS). Planned start Sep 2025; status: not yet recruiting.

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Drugs

ivonescimab
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Conditions

non-small cell lung cancer (NSCLC)Carcinomatous Meningitis (CM)

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