Trial intelligence / Profile preview

MTHFR C677C/T-guided folic acid + vitamin B12 with different antihypertensive regimens in MHD patients with hypertension and coronary heart disease

ChiCTR2500112318Phase 4Not yet recruiting

Sponsor
The Peoples' Hospital of Jiaozuo City
Start
Sep 2025
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Countries
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Overview

Phase 4 trial of folic acid and cyanocobalamin in hypertension (HTN), coronary arteriosclerosis, hyperhomocysteinemia and 1 more (4 arms), sponsored by The Peoples' Hospital of Jiaozuo City. Primary endpoints: Blood pressure during hemodialysis sessions, 24-hour systolic blood pressure average real variability (24h SBP-ARV) and 1 more. Planned start Sep 2025; status: not yet recruiting.

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Drugs

folic acidcyanocobalamin
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Conditions

hypertension (HTN)coronary arteriosclerosishyperhomocysteinemiaend-stage kidney disease (ESKD)

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