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Reduced-dose azacitidine + venetoclax vs azacitidine for maintenance in intermediate–adverse risk AML (MRD-negative CR1)

ChiCTR2500114525Phase 2Not yet recruiting

Sponsor
First Affiliated Hospital of Soochow University
Start
Dec 2025
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, randomised, open-label trial in acute myeloid leukemia (AML) comparing Reduced-dose azacitidine + venetoclax maintenance with Azacitidine maintenance (2 arms). Primary endpoint: Relapse-free survival. Planned start Dec 2025; status: not yet recruiting.

02

Drugs

azacitidinevenetoclax
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Conditions

acute myeloid leukemia (AML)

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