Trial intelligence / Profile preview

TAS-102 + Fruquintinib ± Chidamide + Serplulimab in third-line and beyond metastatic colorectal cancer

ChiCTR2500115578Phase 4Not yet recruiting

Sponsor
First Affiliated Hospital of Soochow University
Start
Dec 2025
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Countries
1
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Overview

Phase 4, randomised trial in metastatic colon cancer (mCRC) comparing TAS-102 + Fruquintinib + Chidamide + Serplulimab with TAS-102 + Fruquintinib (2 arms). Primary endpoints: Safety and Objective response rate. Planned start Dec 2025; status: not yet recruiting.

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Drugs

trifluridine + tipiracilfruquintinibtucidinostatserplulimab
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Conditions

metastatic colon cancer (mCRC)

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