Trial intelligence / Profile preview

SHR-4849 combination therapy in malignant solid tumors (Phase II, multicenter, open-label)

ChiCTR2600117863Phase 2Not yet recruiting

Sponsor
Shandong Cancer Hospital
Start
Jan 2026
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
Countries
1
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Overview

Phase 2, open-label trial of SHR-4849 in small cell lung cancer (SCLC), large cell neuroendocrine carcinoma (LCNEC), neuroendocrine carcinoma (NEC) and 1 more (8 arms), sponsored by Shandong Cancer Hospital. Primary endpoints: Incidence of dose-limiting toxicity (DLT) and Incidence and severity of adverse events (AE) and serious adverse events (SAE). Planned start Jan 2026; status: not yet recruiting.

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Drugs

SHR-4849
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Conditions

small cell lung cancer (SCLC)large cell neuroendocrine carcinoma (LCNEC)neuroendocrine carcinoma (NEC)Nonhematologic neoplasms

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