Trial intelligence / Profile preview

Phase II trial of AHB-137 in treatment-naïve chronic hepatitis B

ChiCTR2600126458Phase 2Not yet recruiting

Sponsor
The 2nd Affiliated Hospital of Chongqing Medical University
Start
Jun 2026
Modality
Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Countries
1
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Overview

Phase 2, randomised trial in Chronic Hepatitis B (CHB) comparing Placebo control with AHB-137 (2 arms). Primary endpoints: Clinical cure 24 weeks after discontinuation of all chronic hepatitis B treatments and High-sensitivity HBsAg < 0.005 IU/mL and HBV DNA < LLOQ (10 IU/mL) at end of treatment. Planned start Jun 2026; status: not yet recruiting.

02

Drugs

AHB-137
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Conditions

Chronic Hepatitis B (CHB)

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