Trial intelligence / Profile preview

Phase 3 randomized double-blind study of bomedemstat versus hydroxyurea in cytoreduction-naive essential thrombocythemia

CTR20250182Phase 3Active

Sponsor
Merck & Co.
Start
Dec 2025
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
Countries
1
01

Overview

Phase 3, randomised, double-blind trial in thrombocythemia comparing Bomedemstat with Hydroxyurea (2 arms). Primary endpoint: Durable clinical hematologic response. Started Dec 2025; status: active.

02

Drugs

bomedemstathydroxyurea
03

Conditions

thrombocythemia

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