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Randomized Phase II Trial of High-Dose MTX + Ara-C ± Thiotepa ± Rituximab, Followed by Brain Irradiation vs. High-Dose Chemotherapy with ASCT in Primary CNS Lymphoma

DRKS00003763Phase 2Completed

Sponsor
Universitätsklinikum Freiburg
Start
May 2012
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Countries
3
01

Overview

Phase 2, randomised, open-label trial of methotrexate, cytarabine, thiotepa, rituximab, carmustine and 1 more in primary central nervous system lymphoma (PCNSL) (5 arms), sponsored by Universitätsklinikum Freiburg. Started May 2012; status: completed.

02

Drugs

methotrexatecytarabinethioteparituximabcarmustine
03

Conditions

primary central nervous system lymphoma (PCNSL)

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