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Methotrexate for knee osteoarthritis pain and quality of life
IRCT20251112067966N1Phase 3Completed
- Sponsor
- Bushehr University of Medical Sciences
- Start
- Jan 2026
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Countries
- 1
01
Overview
Phase 3, randomised, triple-blind trial in knee osteoarthritis (OA) comparing Methotrexate + NSAID with Placebo + NSAID (2 arms). Primary endpoint: Pain reduction and function improvement based on the WOMAC questionnaire. Started Jan 2026; status: completed.
02
Drugs
methotrexate
03
Conditions
knee osteoarthritis (OA)
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