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Feasibility study of pentoxifylline + tocopherol to prevent radiotherapy-related oral and facial complications in head and neck cancer
ISRCTN74484952Phase 2Completed
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Start
- Jul 2019
- Modality
- Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
01
Overview
Phase 2, randomised, open-label trial of pentoxifylline and tocopherol in osteoradionecrosis of the jaws (ORN), trismus and dysphagia (2 arms), sponsored by Guy's and St Thomas' NHS Foundation Trust. Primary endpoints: Feasibility: patient preference for drug formulation and side effects, Feasibility: recruitment, retention, and adherence and 1 more. Started Jul 2019; status: completed.
02
Drugs
pentoxifyllinetocopherol
03
Conditions
osteoradionecrosis of the jaws (ORN)trismusdysphagia
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