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SPOT-IT topical prevention of cutaneous squamous cell carcinoma in immunosuppressed patients
ISRCTN80116429Phase 3Recruiting
- Sponsor
- Cardiff University
- Start
- Feb 2026
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Small Molecules
01
Overview
Phase 3, randomised, open-label trial of fluorouracil and calcipotriol in cutaneous squamous cell carcinoma (cSCC) and actinic keratosis (AK) (3 arms), sponsored by Cardiff University. Primary endpoint: Time to new primary cutaneous squamous cell carcinoma in intervention zones. Started Feb 2026; status: recruiting.
02
Drugs
fluorouracilcalcipotriol
03
Conditions
cutaneous squamous cell carcinoma (cSCC)actinic keratosis (AK)
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