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GCIR trial of gemcitabine + cisplatin + immune checkpoint inhibitor with or without endoscopic radiofrequency ablation in unresectable biliary tract cancer

jRCT1051260084Phase 3Recruiting

Start
Aug 2026
Modality
Small Molecules, PD-1/PD-L1 Inhibitors → Immune Checkpoint Inhibitors → Monoclonal Antibodies → Antibody-Based Therapeutics, Immune Checkpoint Inhibitors → Monoclonal Antibodies → Antibody-Based Therapeutics
Countries
1
01

Overview

Phase 3, randomised, open-label trial of gemcitabine, cisplatin, durvalumab and pembrolizumab in biliary cancer (2 arms). Primary endpoint: Progression-free survival. Started Aug 2026; status: recruiting.

02

Drugs

gemcitabinecisplatindurvalumabpembrolizumab
03

Conditions

biliary cancer

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