Trial intelligence / Profile preview

DESTINY-Lung04 first-line HER2-mutant NSCLC study

jRCT2011210058Phase 3Active, not recruiting

Sponsor
Daiichi Sankyo Co., Ltd.
Start
Jan 2022
Modality
Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
01

Overview

Phase 3, randomised, open-label trial in non-small cell lung cancer (NSCLC) comparing T-DXd with Cisplatin or carboplatin + pemetrexed + pembrolizumab (2 arms). Primary endpoint: Progression-free survival by blinded independent central review. Started Jan 2022; status: active, not recruiting.

02

Drugs

trastuzumab deruxtecancisplatincarboplatinpemetrexedpembrolizumab
03

Conditions

non-small cell lung cancer (NSCLC)

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